{
 "fuente": "Glatfelter GC, Vandeputte MM, Chen L, et al. Alkoxy chain length governs the potency of 2-benzylbenzimidazole 'nitazene' opioids associated with human overdose. Psychopharmacology 240(12):2573-2584 (2023). Tabla 1, columna 'Antinociception (% MPE) ED50 (mg/kg)', media; IC 95% entre corchetes en el original.",
 "doi": "https://doi.org/10.1007/s00213-023-06451-2",
 "texto_completo": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12892259/",
 "transcrito": "2026-10-09",
 "ensayo": "Latencia en placa caliente (antinocicepcion, % MPE) en ratones macho C57BL/6J",
 "ed50_mg_kg": {
  "Morfina": 10.19,
  "Fentanilo": 0.16,
  "Butonitazeno": 1.41,
  "Metonitazeno": 0.31,
  "Protonitazeno": 0.04,
  "Isotonitazeno": 0.021,
  "Etonitazeno": 0.012
 },
 "ic95_mg_kg": {
  "Morfina": [8.32, 12.06],
  "Fentanilo": [0.13, 0.18],
  "Butonitazeno": [1.17, 1.65],
  "Metonitazeno": [0.25, 0.38],
  "Protonitazeno": [0.03, 0.05],
  "Isotonitazeno": [0.018, 0.024],
  "Etonitazeno": [0.009, 0.016]
 }
}